Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 4/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.31 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10810251 | 0.81 | TRPA1 (0.36) | DRD2TRPA1CYP3A4ADORA2AADORA1 | |
| SCHEMBL10680809 | 0.80 | DRD2 (0.36) | DRD2TRPA1CYP3A4PDE3BPDE3A | |
| SCHEMBL10680981 | 0.79 | DRD2 (0.38) | DRD2TRPA1CYP3A4PDE3BPDE3A | |
| SCHEMBL10683067 | 0.79 | KDM4E (0.37) | DRD2TRPA1CYP3A4PDE3BPDE3A | |
| SCHEMBL10676916 | 0.78 | ALDH1A1 (0.46) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL10684915 | 0.78 | CDC7 (0.40) | DRD2TRPA1CYP3A4PDE3BPDE3A | |
| SCHEMBL10680196 | 0.77 | PDE3B (0.58) | CYP3A4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL10682419 | 0.77 | LMNA (0.39) | CYP3A4PDE3BPDE3APDE4APDE4B | |
| SCHEMBL7376126 | 0.76 | PDE3B (0.44) | DRD2TRPA1PDE3BPDE3AMAPT | |
| SCHEMBL7427267 | 0.75 | PDE3B (0.61) | TRPA1CYP3A4PDE3BPDE3APDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |