Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.44 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TNF | P01375 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL556003 | 0.83 | KDM4E (0.55) | HPGDKDM4EBRAFGPR18LMNA | |
| SCHEMBL9176299 | 0.83 | KDM4E (0.65) | HPGDKDM4EBRAFGPR18LMNA | |
| SCHEMBL7430972 | 0.81 | KDM4E (0.53) | HPGDKDM4EBRAFGPR18LMNA | |
| SCHEMBL7441558 | 0.81 | KDM4E (0.56) | HPGDKDM4EBRAFGPR18LMNA | |
| SCHEMBL7761648 | 0.78 | ADORA3 (0.53) | KDM4ESMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL7447211 | 0.77 | HPGD (0.44) | HPGDKDM4ELMNASMN1; SMN2KMT2A | |
| SCHEMBL28749924 | 0.76 | TSHR (0.50) | HPGDKDM4EGPR18LMNASMN1; SMN2 | |
| SCHEMBL16028369 | 0.73 | GPR18 (0.55) | HPGDKDM4EBRAFGPR18SMN1; SMN2 | |
| SCHEMBL9536468 | 0.72 | HPGD (0.47) | HPGDKDM4EBRAFKMT2AMAPT | |
| SCHEMBL7441501 | 0.72 | PCSK9 (0.42) | HPGDBRAFLMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |