Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.56 |
| ▸ | FEN1 | P39748 | 1/20 | 0.56 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.51 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1945591 | 0.89 | MTNR1A (0.59) | SMN1; SMN2MAPTHPGDERCC5FEN1 | |
| Methane SCHEMBL11374227 | 0.87 | MTNR1A (0.57) | SMN1; SMN2MAPTHPGDERCC5FEN1 | |
| SCHEMBL23014298 | 0.82 | RAB9A (0.61) | SMN1; SMN2MAPTL3MBTL1ERCC5FEN1 | |
| SCHEMBL20245219 | 0.80 | SMN1; SMN2 (0.68) | SMN1; SMN2MAPTL3MBTL1HPGDERCC5 | |
| SCHEMBL24590462 | 0.80 | MEN1 (0.63) | SMN1; SMN2MAPTL3MBTL1HPGDERCC5 | |
| SCHEMBL800972 | 0.79 | ERCC5 (0.67) | SMN1; SMN2MAPTL3MBTL1HPGDERCC5 | |
| SCHEMBL7436867 | 0.79 | HSD17B3 (0.52) | MAPTL3MBTL1PTPN1ALDH1A1KDM4E | |
| SCHEMBL7444387 | 0.79 | RAB9A (0.55) | SMN1; SMN2MAPTL3MBTL1GSK3BALDH1A1 | |
| SCHEMBL27182280 | 0.78 | ERCC5 (0.77) | SMN1; SMN2MAPTL3MBTL1HPGDERCC5 | |
| SCHEMBL7440297 | 0.78 | KMT2A (0.54) | SMN1; SMN2MAPTHPGDPTPN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4453003-A | ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS | UMEZAWA HAMAO (JP) | 1984-06-05 | — | — | US | disclosed |
| US-4391986-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediates therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1983-07-05 | — | — | US | disclosed |
| US-4281180-A | Process for producing threo-3-amino-2-hydroxybutanoyl-aminoacetic acids, as well as novel intermediated therefor and process for producing them | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 1981-07-28 | — | — | US | disclosed |