Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | GPR34 | Q9UPC5 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8683167 | 0.89 | POLB (0.42) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7436028 | 0.88 | ALDH1A1 (0.41) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7435258 | 0.88 | GPR34 (0.47) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7435245 | 0.88 | GPR34 (0.47) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7347734 | 0.87 | GPR34 (0.54) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7347741 | 0.87 | GPR34 (0.54) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7437147 | 0.87 | HPGD (0.45) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7433236 | 0.85 | PSMB1 (0.46) | ALDH1A1 | |
| SCHEMBL7444208 | 0.85 | ALDH1A1 (0.46) | ALDH1A1POLBMAPTUSP2HPGD | |
| SCHEMBL7444214 | 0.85 | ALDH1A1 (0.46) | ALDH1A1POLBMAPTUSP2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0525420-B1 | Pseudopeptides and dipeptides characterised by a substituted methyl ketone moiety at the C-terminus as thiol protease inhibitors | MITSUBISHI CHEM CORP (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5834508-A | PROTEASE ENZYME INHIBITORS; MUSCLE DISORDERS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1998-11-10 | — | — | US | disclosed |
| US-5639783-A | POTENT PROTEASE INHIBITOR FOR TREATING MUSCULAR, NERVOUS SYSTEM DISEASES | MITSUBISHI CHEMICAL CORPORATION (JP) | 1997-06-17 | — | — | US | disclosed |