Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | GHSR | Q92847 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CCKAR | P32238 | 1/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | MME | P08473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433678 | 0.98 | GHSR (0.37) | MAPTXBP1NPSR1TDP1CYP1A2 | |
| SCHEMBL7431147 | 0.92 | MAPT (0.40) | MAPTGHSRPOLB | |
| SCHEMBL7442699 | 0.89 | MAPT (0.35) | MAPTXBP1NPSR1TDP1GHSR | |
| SCHEMBL7441953 | 0.89 | GHSR (0.35) | MAPTGHSRCCKARCCKBRLTA4H | |
| SCHEMBL7441596 | 0.89 | GHSR (0.34) | MAPTXBP1NPSR1TDP1GHSR | |
| SCHEMBL7441643 | 0.87 | CCKAR (0.34) | MAPTXBP1NPSR1TDP1GHSR | |
| SCHEMBL7439595 | 0.86 | GHSR (0.36) | MAPTXBP1NPSR1TDP1GHSR | |
| SCHEMBL7433296 | 0.86 | CACNA1B (0.32) | MAPTXBP1NPSR1TDP1GHSR | |
| SCHEMBL7433464 | 0.86 | MAP3K5 (0.33) | MAPTXBP1NPSR1TDP1CYP1A2 | |
| SCHEMBL7446446 | 0.83 | CTSL (0.38) | MAPTXBP1NPSR1TDP1GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |