Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 4/20 | 0.32 |
| ▸ | GHSR | Q92847 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | CCKAR | P32238 | 1/20 | 0.31 |
| ▸ | CCKBR | P32239 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | PARP1 | P09874 | 1/20 | 0.30 |
| ▸ | XBP1 | P17861 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435675 | 0.86 | MAPT (0.37) | GHSRMAPTCCKARCCKBRLTA4H | |
| SCHEMBL7436456 | 0.85 | LTA4H (0.34) | CACNA1BPTGER4MAPTCTSLLTA4H | |
| SCHEMBL7433678 | 0.84 | GHSR (0.37) | GHSRMAPTCCKARCCKBRLTA4H | |
| SCHEMBL7441953 | 0.84 | GHSR (0.35) | CACNA1BGHSRMAP3K5MAPTCCKAR | |
| SCHEMBL7442699 | 0.83 | MAPT (0.35) | GHSRMAP3K5MAPTCCKARCCKBR | |
| SCHEMBL7441596 | 0.82 | GHSR (0.34) | GHSRMAPTCCKARCCKBRLTA4H | |
| SCHEMBL7441643 | 0.81 | CCKAR (0.34) | GHSRMAP3K5MAPTCCKARCCKBR | |
| SCHEMBL7431147 | 0.81 | MAPT (0.40) | GHSRMAPTPOLB | |
| SCHEMBL7446446 | 0.80 | CTSL (0.38) | GHSRMAPTCTSLCCKARCCKBR | |
| SCHEMBL7439595 | 0.80 | GHSR (0.36) | GHSRMAP3K5MAPTCCKARCCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5710153-A | INTERLEUKIN CONVERTING ENZYME INHIBITORS | ONO PHRAMACEUTICAL CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0761680-A2 | Tetrazole compounds having Interleukin-1beta converting enzyme inhibitory activity | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-03-12 | — | — | EP | disclosed |