Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 14/20 | 0.41 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433916 | 0.86 | REN (0.36) | RENMMP2METAP2 | |
| SCHEMBL7432099 | 0.82 | REN (0.38) | RENMETAP2 | |
| SCHEMBL21114839 | 0.78 | CTSL (0.46) | — | |
| SCHEMBL21114840 | 0.78 | CTSL (0.46) | — | |
| SCHEMBL23149336 | 0.78 | CTSL (0.46) | — | |
| SCHEMBL23834229 | 0.78 | REN (0.37) | RENMMP1MMP2 | |
| SCHEMBL23834231 | 0.78 | REN (0.37) | RENMMP1MMP2 | |
| SCHEMBL1862727 | 0.75 | LTA4H (0.43) | RENMETAP2 | |
| SCHEMBL23834045 | 0.74 | REN (0.44) | RENMMP1MMP2METAP2EPHX2 | |
| SCHEMBL23834041 | 0.74 | REN (0.44) | RENMMP1MMP2METAP2EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217958-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| WO-1989007940-A1 | 1,2-HYDROXY PHOSPHONATES AND DERIVATIVES THEREOF | E.R. SQUIBB & SONS, INC. (US) | 1989-09-08 | — | — | WO | disclosed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | disclosed |