Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | GRN | P28799 | 1/20 | 0.35 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 3/20 | 0.35 |
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7435765 | 0.86 | REN (0.41) | RENMETAP2MMP2 | |
| SCHEMBL7432099 | 0.82 | REN (0.38) | RENLTA4HGRNSORT1CTSK | |
| SCHEMBL7440606 | 0.81 | REN (0.44) | REN | |
| SCHEMBL1862727 | 0.77 | LTA4H (0.43) | RENLTA4HGRNSORT1CTSK | |
| SCHEMBL7268424 | 0.76 | REN (0.41) | RENLTA4HCTSKCTSSMETAP2 | |
| SCHEMBL7440602 | 0.75 | REN (0.39) | REN | |
| SCHEMBL7429573 | 0.75 | REN (0.50) | RENCTSKCTSSCTSLCTSB | |
| SCHEMBL7426913 | 0.74 | CTSK (0.33) | RENLTA4HGRNSORT1CTSK | |
| SCHEMBL9226159 | 0.74 | REN (0.45) | RENLTA4HCTSK | |
| SCHEMBL7280734 | 0.74 | REN (0.45) | RENLTA4HCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5217958-A | Hypotensive agents | E. R. SQUIBB & SONS, INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0331105-A2 | 1,2-Hydroxy phosphonates and derivatives thereof | E.R. Squibb & Sons, Inc. (US) | 1989-09-06 | — | — | EP | disclosed |