Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HK1 | P19367 | 1/20 | 0.60 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.60 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.44 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.44 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444038 | 0.84 | ALDH1A1 (0.51) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL7437724 | 0.83 | ATP4A (0.61) | ALDH1A1MAPTRAB9AGAALMNA | |
| SCHEMBL7429814 | 0.83 | KDM4E (0.60) | ALDH1A1MAPTMEN1KMT2ALMNA | |
| SCHEMBL7437056 | 0.83 | ATP4A (0.61) | ALDH1A1MAPTRAB9ACSNK2A2CSNK2B | |
| SCHEMBL7436415 | 0.83 | MAPT (0.63) | ALDH1A1MAPTRAB9AHPGDHK1 | |
| SCHEMBL7438472 | 0.82 | RAB9A (0.59) | ALDH1A1MAPTRAB9AHPGDMEN1 | |
| SCHEMBL7441627 | 0.82 | ALDH1A1 (0.61) | ALDH1A1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL7426086 | 0.80 | ALDH1A1 (0.51) | ALDH1A1MAPTCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL7429092 | 0.80 | CFTR (0.47) | ALDH1A1MAPTLMNAHTTHIF1A | |
| SCHEMBL7428970 | 0.79 | NPC1 (0.59) | ALDH1A1MAPTRAB9AHPGDCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |