Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | CCR8 | P51685 | 2/20 | 0.42 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.36 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665059 | 0.78 | PDE4A (0.53) | CCR1CCR5CCR8PDE4APDE4B | |
| SCHEMBL4734303 | 0.75 | CCR1 (0.35) | CCR1CCR5CCR8PDE4APDE4B | |
| SCHEMBL12013398 | 0.71 | PDE4A (0.41) | CCR1CCR5CCR8PDE4APDE4B | |
| SCHEMBL16274073 | 0.68 | CYP17A1 (0.51) | RAB9ACYP17A1MAPTCYP11B1CYP11B2 | |
| SCHEMBL19783279 | 0.68 | CCR1 (0.36) | CCR1CCR5CCR8KDM4EPSMD14 | |
| SCHEMBL2850764 | 0.68 | PSMD14 (0.65) | CCR1CCR5CCR8KDM4EPSMD14 | |
| SCHEMBL19540958 | 0.68 | CYP11B1 (0.51) | CYP17A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL7445231 | 0.67 | KDM4E (0.43) | CCR1CCR5CCR8PDE4APDE4B | |
| SCHEMBL19782773 | 0.67 | NOS1 (0.38) | CCR1CCR5CCR8KDM4ERAB9A | |
| SCHEMBL7449180 | 0.67 | L3MBTL1 (0.45) | PDE4APDE4BPDE4CPDE4DKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1202170-A | Quinoline derivatives as type 1V phosphodiesterase inhibitors | NOVARTIS AG (CH) | 1998-12-16 | — | — | CN | disclosed |
| EP-0873338-A1 | QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | Novartis AG (CH) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997018208-A1 | QUINOLINE DERIVATIVES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | NOVARTIS AG (CH) | 1997-05-22 | — | — | WO | disclosed |