Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.58 |
| ▸ | HPGDS | O60760 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.47 |
| ▸ | KMO | O15229 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31401008 | 0.87 | KDM4E (0.60) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL7442976 | 0.84 | SCN9A (0.62) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL7088488 | 0.84 | TSHR (0.59) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL7429814 | 0.83 | KDM4E (0.60) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL7436415 | 0.82 | MAPT (0.63) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL6660829 | 0.82 | ATP4A (0.60) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL6664214 | 0.82 | ATP4A (0.60) | MEN1MAPTKMT2ACYP2C9CYP3A4 | |
| SCHEMBL7440522 | 0.82 | CYP3A4 (0.61) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL4640043 | 0.81 | ALOX5 (0.59) | KDM4EMEN1MAPTKMT2ACYP2C9 | |
| SCHEMBL168593 | 0.81 | ALDH1A1 (0.56) | KDM4EMEN1MAPTKMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0506194-B1 | 4-aryl-thiazole or imidazole derivatives | AKZO NOBEL NV (NL) | 1996-08-21 | — | — | EP | disclosed |
| US-5462959-A | 4-aryl-imidazole derivatives | AKZO N.V. (NL) | 1995-10-31 | — | — | US | disclosed |
| US-5254575-A | 4-aryl-thiazole derivatives | AKZO N.V. (NL) | 1993-10-19 | — | — | US | disclosed |
| EP-0506194-A1 | 4-aryl-thiazole or imidazole derivatives | Akzo Nobel N.V. (NL) | 1992-09-30 | — | — | EP | disclosed |