Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.71 |
| ▸ | KDR | P35968 | 2/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.64 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.62 |
| ▸ | ESR1 | P03372 | 6/20 | 0.61 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.61 |
| ▸ | HRH1 | P35367 | 1/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899201 | 0.84 | LTA4H (1.00) | LTA4HBACE1HRH3HRH1KCNH2 | |
| SCHEMBL8264185 | 0.82 | LTA4H (0.69) | LTA4HBACE1HRH3HRH1KCNH2 | |
| SCHEMBL6955456 | 0.82 | LTA4H (0.72) | LTA4HBACE1HRH3HRH1KCNH2 | |
| SCHEMBL14451861 | 0.82 | LTA4H (0.70) | LTA4HBACE1HRH3HRH1KCNH2 | |
| SCHEMBL14970484 | 0.82 | LTA4H (0.97) | LTA4HBACE1HRH3HRH1KCNH2 | |
| SCHEMBL7444934 | 0.82 | KDR (0.56) | LTA4HKDRBACE1ESR1ESR2 | |
| SCHEMBL21359400 | 0.82 | KDR (0.70) | KDRHRH3HRH1KCNH2 | |
| SCHEMBL5175647 | 0.81 | LTA4H (0.60) | LTA4HKDRHRH3ESR1ESR2 | |
| SCHEMBL6960875 | 0.81 | LTA4H (0.78) | LTA4HBACE1HRH3HRH1KCNH2 | |
| SCHEMBL2475993 | 0.80 | ESR1 (0.75) | LTA4HHRH3ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |