Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 3/20 | 0.69 |
| ▸ | BACE1 | P56817 | 1/20 | 0.67 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | HRH1 | P35367 | 1/20 | 0.62 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8266135 | 0.90 | BACE1 (0.77) | LTA4HBACE1HRH3KDM4EL3MBTL1 | |
| SCHEMBL8263650 | 0.89 | RAB9A (0.63) | LTA4HBACE1HRH3KDM4EL3MBTL1 | |
| SCHEMBL259391 | 0.84 | KDM4E (0.86) | LTA4HBACE1HRH3KDM4EL3MBTL1 | |
| SCHEMBL7447133 | 0.84 | HRH3 (0.73) | LTA4HHRH3KDM4EKCNH2HRH1 | |
| SCHEMBL14970484 | 0.84 | LTA4H (0.97) | LTA4HBACE1HRH3KCNH2HRH1 | |
| SCHEMBL14451861 | 0.84 | LTA4H (0.70) | LTA4HBACE1HRH3KCNH2HRH1 | |
| SCHEMBL6955456 | 0.84 | LTA4H (0.72) | LTA4HBACE1HRH3KCNH2HRH1 | |
| SCHEMBL8361480 | 0.83 | KDM4E (0.83) | LTA4HBACE1KDM4EL3MBTL1 | |
| SCHEMBL1899201 | 0.82 | LTA4H (1.00) | LTA4HBACE1HRH3KCNH2HRH1 | |
| SCHEMBL7436764 | 0.82 | LTA4H (0.71) | LTA4HBACE1HRH3KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2177518-A1 | Organic compounds | Novartis AG (CH) | 2010-04-21 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |