Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 4/20 | 0.53 |
| ▸ | CCR8 | P51685 | 4/20 | 0.53 |
| ▸ | CCR5 | P51681 | 2/20 | 0.53 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.53 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7440672 | 0.85 | CCR1 (0.57) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7437244 | 0.85 | CCR1 (0.50) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7440046 | 0.85 | PDE4A (0.54) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7438319 | 0.84 | CCR1 (0.47) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7431186 | 0.81 | PDE4A (0.61) | CCR1CCR8CCR5L3MBTL1PDE4A | |
| SCHEMBL16581166 | 0.78 | MMP2 (0.54) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL18434453 | 0.78 | L3MBTL1 (0.57) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL7437773 | 0.78 | CCR1 (0.43) | CCR1CCR8CCR5L3MBTL1PDE4A | |
| SCHEMBL31135866 | 0.76 | PSMD14 (0.62) | CCR1CCR8CCR5PSMD14COPS5 | |
| SCHEMBL11087820 | 0.76 | PSMD14 (0.62) | CCR1CCR8CCR5PSMD14COPS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691966-B1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX INC (US) | 1998-09-09 | — | — | EP | disclosed |
| EP-0691966-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1996-01-17 | — | — | EP | disclosed |
| US-5455252-A | Antiinflammatory agent, immunosuppressant, antiallergen, skin disorders, bronchodilator, analgesic | SYNTEX (U.S.A.) INC. (US) | 1995-10-03 | — | — | US | disclosed |
| WO-1994022852-A1 | QUINOLINES AS TYPE IV PHOSPHODIESTERASE INHIBITORS | SYNTEX (U.S.A.) INC. (US) | 1994-10-13 | — | — | WO | disclosed |