Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.43 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.43 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.43 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SCN1A | P35498 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9506294 | 0.89 | GAA (0.33) | GAATSHRCACNA1CCACNA1FCACNA1D | |
| SCHEMBL9506325 | 0.87 | GAA (0.38) | GAATSHRCACNA1CCACNA1FCACNA1D | |
| SCHEMBL7271327 | 0.87 | CACNA1C (0.60) | TSHRCACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7272727 | 0.80 | ADORA3 (0.42) | GAATSHRCACNA1CCACNA1FCACNA1D | |
| SCHEMBL7271021 | 0.79 | CACNA1D (0.54) | TSHRCACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7280639 | 0.79 | LMNA (0.54) | GAATSHRCACNA1CCACNA1FCACNA1D | |
| SCHEMBL7278457 | 0.78 | ADORA3 (0.41) | GAATSHRCACNA1CCACNA1FCACNA1D | |
| SCHEMBL7272702 | 0.78 | MEN1 (0.58) | TSHRCACNA1CCACNA1FCACNA1DCACNA1S | |
| SCHEMBL7271096 | 0.77 | CA1 (0.46) | GAATSHRCACNA1CCACNA1FCACNA1D | |
| SCHEMBL7282275 | 0.76 | CA1 (0.49) | GAATSHRCACNA1CCACNA1FCACNA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361382-B1 | ANTIEPILEPTIC PYRAZOLOPYRIDINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-16 | — | — | EP | claimed |
| US-4916140-A | CALCIUM CHANNEL BLOCKERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-10 | — | — | US | claimed |
| EP-0355234-A1 | Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-28 | — | — | EP | claimed |
| EP-0361382-B1 | ANTIEPILEPTIC PYRAZOLOPYRIDINES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-16 | — | — | EP | disclosed |
| US-4916140-A | CALCIUM CHANNEL BLOCKERS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0355234-A1 | Pyrazolopyridine derivatives as antiatherosclerotic and antihypercholesterolemic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-02-28 | — | — | EP | disclosed |