Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 2/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280324 | 0.90 | ALDH1A1 (0.48) | ADORA3KDM4EHSD17B10CASP1ALDH1A1 | |
| SCHEMBL7272356 | 0.88 | ALDH1A1 (0.42) | ADORA3KDM4EHSD17B10CASP1ALDH1A1 | |
| SCHEMBL7280492 | 0.88 | CACNA1C (0.53) | ACHECACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7282275 | 0.88 | CA1 (0.49) | CA1CA2ADORA3KDM4EHSD17B10 | |
| SCHEMBL7280765 | 0.87 | CACNA1D (0.54) | ADORA3KDM4EHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL7282581 | 0.86 | ALDH1A1 (0.38) | CA1CA2KDM4EALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL7272589 | 0.86 | LMNA (0.37) | CA1CA2ADORA3KDM4EHSD17B10 | |
| SCHEMBL7272932 | 0.84 | CACNA1C (0.53) | CA1CA2ADORA3KDM4EHSD17B10 | |
| SCHEMBL7272872 | 0.81 | MTOR (0.58) | ADORA3KDM4EHSD17B10CASP1ALDH1A1 | |
| SCHEMBL7273223 | 0.79 | CACNA1F (0.55) | ADORA3KDM4EALDH1A1TSHRACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | claimed |
| EP-0114273-B1 | NEW PHARMACOLOGICALLY ACTIVE PYRAZOLOPYRIDINES | GRUPPO LEPETIT S.p.A. (IT) | 1991-11-06 | — | — | EP | disclosed |
| US-4954508-A | HYPOTENSIVE | GRUPPO LEPETIT S.P.A. (IT) | 1990-09-04 | — | — | US | disclosed |
| EP-0114273-A1 | New pharmacologically active pyrazolopyridines | GRUPPO LEPETIT S.p.A. (IT) | 1984-08-01 | — | — | EP | disclosed |