Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.31 |
| ▸ | PEPD | P12955 | 1/20 | 0.30 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.30 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.30 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.30 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7434448 | 0.98 | REN (0.33) | RENANPEPDNPEPPEPDXPNPEP1 | |
| SCHEMBL22250100 | 0.77 | SHBG (0.30) | — | |
| SCHEMBL7441663 | 0.69 | SLC2A1 (0.37) | RENXPNPEP1 | |
| SCHEMBL7443370 | 0.69 | CA1 (0.43) | REN | |
| Hydrochloric Acid SCHEMBL7436251 | 0.68 | SLC2A1 (0.40) | REN | |
| SCHEMBL27939257 | 0.66 | ALDH1A1 (0.30) | — | |
| SCHEMBL7279876 | 0.66 | REN (0.55) | REN | |
| SCHEMBL9417316 | 0.66 | REN (0.45) | REN | |
| SCHEMBL10893754 | 0.65 | TSHR (0.45) | ANPEPDNPEP | |
| SCHEMBL7359493 | 0.65 | CYP2C19 (0.42) | RENANPEPXPNPEP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4826815-A | HYPOTENSIVE | ABBOTT LABORATORIES (US) | 1989-05-02 | — | — | US | disclosed |
| US-4645759-A | HYPOTENSIVE AGENTS | ABBOTT LABORATORIES (US) | 1987-02-24 | — | — | US | disclosed |
| EP-0172347-A2 | Renin inhibiting compounds | ABBOTT LABORATORIES (US) | 1986-02-26 | — | — | EP | disclosed |