Sugi Predict

Sugi Predict / Compounds / SCHEMBL743882

SCHEMBL743882

SCHEMBL743882

O=C(c1cc[c]nc1)N1CCOCC1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.57
▸ ALDH1A1 P00352 4/20 0.55
▸ PHGDH O43175 1/20 0.51
▸ HPGD P15428 7/20 0.49
▸ TSHR P16473 1/20 0.49
▸ POLB P06746 2/20 0.48
▸ KDM4E B2RXH2 2/20 0.48
▸ ALOX15 P16050 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ L3MBTL1 Q9Y468 3/20 0.48
▸ KMT2A Q03164 2/20 0.48
▸ DNMT1 P26358 1/20 0.48
▸ PTPN7 P35236 1/20 0.48
▸ TDP1 Q9NUW8 1/20 0.48
▸ PKM P14618 1/20 0.48
▸ GRM5 P41594 1/20 0.47
▸ AKR1C3 P42330 1/20 0.47
▸ MAPK1 P28482 1/20 0.46
▸ MAPT P10636 1/20 0.46
▸ HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28837058 0.94 SMN1; SMN2 (0.52) SMN1; SMN2ALDH1A1PHGDHHPGDTSHR
SCHEMBL743014 0.85 HPGD (0.53) SMN1; SMN2ALDH1A1HPGDTSHRPOLB
SCHEMBL23388092 0.85 HPGD (0.48) SMN1; SMN2ALDH1A1HPGDPOLBKDM4E
SCHEMBL2536712 0.84 HPGD (0.56) ALDH1A1HPGDTSHRPOLBKDM4E
SCHEMBL2347324 0.81 POLB (0.51) HPGDTSHRPOLBKDM4EALOX15
SCHEMBL23387920 0.81 HPGD (0.51) SMN1; SMN2ALDH1A1HPGDHSD17B10KMT2A
SCHEMBL23387939 0.80 GLRA1 (0.50) SMN1; SMN2ALDH1A1HPGDHSD17B10KMT2A
SCHEMBL15758159 0.80 SMN1; SMN2 (0.55) SMN1; SMN2ALDH1A1PHGDHHPGDTSHR
SCHEMBL23388061 0.80 GRM5 (0.47) L3MBTL1GRM5HTT
SCHEMBL28837079 0.79 GRM5 (0.43) SMN1; SMN2ALDH1A1KDM4EGRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 91 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115003663-B Novel heteroaryl-triazole compounds as pesticides 拜耳公司 2024-04-30 — — CN claimed
US-20230058623-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES ELANCO ANIMAL HEALTH GMBH (DE) 2023-02-23 — — US claimed
US-20230028441-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES ELANCO ANIMAL HEALTH GMBH (DE) 2023-01-26 — — US claimed
CN-115003663-A Novel heteroaryl-triazole compounds as pesticides 拜耳公司 2022-09-02 — — CN claimed
WO-2021099303-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2021-05-27 — — WO claimed
WO-2021069567-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 2021-04-15 — — WO claimed
US-10842803-B2 Imidazopyridines Syk inhibitors Kronos Bio, Inc. (US) 2020-11-24 — — US claimed
US-20190117679-A1 IMIDAZOPYRIDINES SYK INHIBITORS Kronos Bio, Inc. 2019-04-25 — — US claimed
US-9321756-B2 Azole compounds as PIM inhibitors AMGEN INC. (US) 2016-04-26 — — US claimed
CN-104203937-A 8-fluorophthalazin-1 (2h) - one compounds as inhibitors of btk activity HOFFMANN LA ROCHE 2014-12-10 — — CN claimed
US-8362003-B2 3-aminopyrrolidine derivatives as modulators of chemokine receptors INCYTE CORPORATION (US) 2013-01-29 — — US claimed
EP-2545052-A1 IMIDAZOPYRIDINES SYK INHIBITORS Gilead Connecticut, Inc. (US) 2013-01-16 — — EP claimed
EP-2431357-A2 3-Aminopyrrolidine Derivatives as Modulators of Chemokine Receptors Incyte Corporation (US) 2012-03-21 — — EP claimed
US-20110251168-A1 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION 2011-10-13 — — US claimed
WO-2011112995-A1 IMIDAZOPYRIDINES SYK INHIBITORS GILEAD SCIENCES, INC. (US) 2011-09-15 — — WO claimed
EP-1565436-A4 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORP (US) 2007-07-18 — — EP claimed
US-20060252751-A1 3-Aminopyrrolidine derivaties as modulators of chemokine receptors INCYTE HOLDINGS CORPORATION 2006-11-09 — — US claimed
JP-2006516145-A — — 2006-06-22 — — JP claimed
EP-1565436-A2 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2005-08-24 — — EP claimed
WO-2004050024-A2 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS INCYTE CORPORATION (US) 2004-06-17 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190117679-A1 IMIDAZOPYRIDINES SYK INHIBITORS SYK, BTK, ZAP70 SMN1; SMN2 2404/4885ALDH1A1 3956/4885PHGDH 3373/4885
US-20060252751-A1 3-Aminopyrrolidine derivaties as modulators of chemokine receptors CCR2, CXCR3, CCR5 SMN1; SMN2 4815/4885ALDH1A1 2501/4885PHGDH 3988/4885
US-20230028441-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES PRXL2A, GLRX3, CYP4F3 SMN1; SMN2 4634/4885ALDH1A1 4213/4885PHGDH 4479/4885
US-10842803-B2 Imidazopyridines Syk inhibitors SYK, BTK, ZAP70 SMN1; SMN2 2404/4885ALDH1A1 3956/4885PHGDH 3373/4885
US-20110251168-A1 3-AMINOPYRROLIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS CCR2, CXCR3, CCR5 SMN1; SMN2 4846/4885ALDH1A1 2447/4885PHGDH 4184/4885
US-20230058623-A1 NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES PRXL2A, GLRX3, CYP4F3 SMN1; SMN2 4634/4885ALDH1A1 4213/4885PHGDH 4479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.