Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | FCER2 | P06734 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MRE11 | P49959 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | CPA1 | P15085 | 2/20 | 0.37 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7450894 | 0.82 | MME (0.52) | MMEFCER2CYP3A4MAPK1ACE | |
| SCHEMBL7609959 | 0.76 | MME (0.57) | MMEITGB1ITGA4PTPN1ACE | |
| SCHEMBL20474596 | 0.74 | CTSC (0.48) | MMEITGB1ITGA4PTPN1CTSK | |
| SCHEMBL18554154 | 0.74 | CTSC (0.48) | MMEITGB1ITGA4PTPN1CTSK | |
| SCHEMBL4018176 | 0.73 | SLC22A12 (0.42) | MMEITGB1ITGA4PTPN1MRE11 | |
| SCHEMBL4018178 | 0.73 | SLC22A12 (0.42) | MMEITGB1ITGA4PTPN1MRE11 | |
| SCHEMBL27792670 | 0.72 | MMP8 (0.46) | — | |
| SCHEMBL4448448 | 0.72 | CYP19A1 (0.41) | MMEITGB1ITGA4PTPN1MRE11 | |
| SCHEMBL8837469 | 0.70 | FCER2 (0.50) | MMEFCER2CYP3A4MAPK1ACE | |
| SCHEMBL3178122 | 0.69 | CYP19A1 (0.51) | MMECTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888299-A1 | SULPHUR DERIVATIVES WITH A RETROAMIDE BOND AS ENDOTHELIN-CONVERTING ENZYME INHIBITORS | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032849-A1 | SULPHUR DERIVATIVES WITH A RETROAMIDE BOND AS ENDOTHELIN-CONVERTING ENZYME INHIBITORS | HOECHST MARION ROUSSEL (FR) | 1997-09-12 | — | — | WO | disclosed |