Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | RARG | P13631 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.49 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.49 |
| ▸ | ACE | P12821 | 1/20 | 0.48 |
| ▸ | FCER2 | P06734 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837469 | 0.85 | FCER2 (0.50) | MMECYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL9068533 | 0.84 | MME (0.62) | MMECYP3A4MAPK1ACEPAM | |
| SCHEMBL9587602 | 0.84 | MME (0.48) | MMECYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL9587952 | 0.83 | MME (0.47) | MMECYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL7439103 | 0.82 | MME (0.43) | MMECYP3A4MAPK1ACEFCER2 | |
| SCHEMBL9588793 | 0.81 | CYP3A4 (0.46) | MMECYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL7298881 | 0.81 | MME (0.58) | MMECYP3A4MAPK1CYP1A2CYP2D6 | |
| SCHEMBL18576675 | 0.81 | CTRB1 (0.65) | CYP3A4CYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7608505 | 0.80 | CTRB1 (0.65) | MME | |
| SCHEMBL7608499 | 0.80 | CTRB1 (0.65) | MME |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020161030-A1 | Sulpur derivatives containing a retroamide bond as inhibitors of endothelin-converting enzymes | HOECHST MARION ROUSSEL | 2002-10-31 | — | — | US | disclosed |
| EP-0888299-A1 | SULPHUR DERIVATIVES WITH A RETROAMIDE BOND AS ENDOTHELIN-CONVERTING ENZYME INHIBITORS | HOECHST MARION ROUSSEL (FR) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032849-A1 | SULPHUR DERIVATIVES WITH A RETROAMIDE BOND AS ENDOTHELIN-CONVERTING ENZYME INHIBITORS | HOECHST MARION ROUSSEL (FR) | 1997-09-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161030-A1 | Sulpur derivatives containing a retroamide bond as inhibitors of endothelin-converting enzymes | EDNRA, ECE1, EDNRB | MME 8/4885CYP3A4 1062/4885MAPK1 3000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.