Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.46 |
| ▸ | MAOA | P21397 | 6/20 | 0.46 |
| ▸ | PRKCQ | Q04759 | 6/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | MYC | P01106 | 1/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7437915 | 0.84 | MAOB (0.42) | MAOBMAOAPRKCQPRKCDFFAR1 | |
| SCHEMBL27370060 | 0.82 | FFAR1 (0.42) | MAOBMAOAPRKCQPRKCDFFAR1 | |
| SCHEMBL8481860 | 0.80 | MAOB (0.62) | MAOBMAOA | |
| SCHEMBL5034698 | 0.77 | MAOB (0.57) | MAOBMAOAPRKCQPRKCD | |
| SCHEMBL8179409 | 0.77 | MAOB (0.48) | MAOBMAOA | |
| SCHEMBL8487461 | 0.74 | MAOB (0.40) | MAOBMAOAPRKCQPRKCDMYC | |
| SCHEMBL7442248 | 0.74 | HTR7 (0.36) | HTR7MYCWDR5 | |
| SCHEMBL1602282 | 0.74 | S1PR1 (0.48) | MAOBMAOAFFAR1HDAC6 | |
| SCHEMBL8482882 | 0.74 | MAOB (0.39) | MAOBMAOAPRKCQPRKCDMYC | |
| SCHEMBL8808908 | 0.73 | MAOB (0.39) | MAOBMAOAPRKCQPRKCDHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |