Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.55 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | HTR2A | P28223 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.55 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428553 | 1.00 | HTR1A (0.55) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL7431242 | 0.99 | HTR1A (0.56) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL7441338 | 0.83 | SIGMAR1 (0.59) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL8553726 | 0.82 | SIGMAR1 (0.56) | — | |
| SCHEMBL9372029 | 0.79 | DRD2 (0.60) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL7436502 | 0.79 | SIGMAR1 (0.56) | OPRL1 | |
| SCHEMBL7435741 | 0.75 | HTR1A (0.60) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL7441303 | 0.75 | HTR1A (0.64) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL5170230 | 0.74 | HTR1A (0.81) | HTR1ADRD2HTR2ASLC6A4HRH1 | |
| SCHEMBL6993758 | 0.74 | TMEM97 (0.75) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207677-B1 | ADMINISERING SIGMA RECEPTOR BINDING PIPERIDINE DERIVATIVE FOR TREATING ANXIETY, EPILEPSY, CONVULSION, MOVEMENT DISORDER, AMNESIA | H. LUNDBECK A/S (DK) | 2001-03-27 | — | — | US | disclosed |
| US-6031099-A | Piperidine derivates having anxiolytic effect | H. LUNDBECK A/S (DK) | 2000-02-29 | — | — | US | disclosed |
| EP-0593511-B1 | PIPERIDINE DERIVATES HAVING ANXIOLYTIC EFFECT | LUNDBECK & CO AS H (DK) | 1998-09-02 | — | — | EP | disclosed |
| EP-0859004-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-08-19 | — | — | EP | disclosed |
| EP-0853085-A1 | Piperidine derivatives having anxiolytic effect | H. LUNDBECK A/S (DK) | 1998-07-15 | — | — | EP | disclosed |
| US-5665725-A | Piperidine derivatives having anxiolytic effect | Lundbeck, H. (DK) | 1997-09-09 | — | — | US | disclosed |
| EP-0518805-A1 | Piperidine derivatives | H. LUNDBECK A/S (DK) | 1992-12-16 | — | — | EP | disclosed |