Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 13/20 | 0.51 |
| ▸ | CASP7 | P55210 | 10/20 | 0.51 |
| ▸ | CASP1 | P29466 | 6/20 | 0.51 |
| ▸ | CASP9 | P55211 | 3/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CASP2 | P42575 | 3/20 | 0.44 |
| ▸ | CASP6 | P55212 | 3/20 | 0.44 |
| ▸ | CASP4 | P49662 | 2/20 | 0.44 |
| ▸ | CASP8 | Q14790 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6954700 | 0.88 | CASP3 (0.49) | CASP3CASP7CASP1CASP9GAA | |
| SCHEMBL8307047 | 0.88 | CASP3 (0.49) | CASP3CASP7CASP1CASP9GAA | |
| SCHEMBL7433422 | 0.81 | PSEN1 (0.56) | CASP3CASP7CASP9PSEN1PSEN2 | |
| SCHEMBL8307728 | 0.81 | CASP3 (0.68) | CASP3CASP7CASP1CASP9 | |
| SCHEMBL6947728 | 0.81 | CASP3 (0.68) | CASP3CASP7CASP1CASP9 | |
| SCHEMBL6951145 | 0.78 | FKBP1A (0.58) | CASP3CASP7GAAPOLB | |
| SCHEMBL6954598 | 0.76 | GAA (0.63) | CASP3CASP7CASP1CASP9GAA | |
| SCHEMBL7077522 | 0.75 | GAA (0.61) | CASP3CASP7CASP1CASP9GAA | |
| SCHEMBL5808164 | 0.74 | PSEN1 (0.56) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7444177 | 0.74 | CYP3A4 (0.57) | CASP3CASP7CASP1CASP9GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |