Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.56 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.56 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.56 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.56 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.56 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 2/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP9 | P55211 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307728 | 0.81 | CASP3 (0.68) | CASP3CASP7CASP9 | |
| SCHEMBL6947728 | 0.81 | CASP3 (0.68) | CASP3CASP7CASP9 | |
| SCHEMBL7440426 | 0.81 | CASP3 (0.51) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6951145 | 0.80 | FKBP1A (0.58) | GAAALDH1A1LMNACASP3CASP7 | |
| SCHEMBL6954598 | 0.80 | GAA (0.63) | GAAALDH1A1CASP3CASP7CASP9 | |
| SCHEMBL7430586 | 0.80 | GAA (0.60) | GAAALDH1A1HTTLMNAKMT2A | |
| SCHEMBL8307047 | 0.80 | CASP3 (0.49) | GAACASP3CASP7CASP9 | |
| SCHEMBL6954700 | 0.80 | CASP3 (0.49) | GAACASP3CASP7CASP9 | |
| SCHEMBL7077522 | 0.79 | GAA (0.61) | GAAALDH1A1CASP3CASP7CASP9 | |
| SCHEMBL6948048 | 0.76 | ALDH1A1 (0.57) | GAAALDH1A1CASP3KMT2AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | claimed |
| US-6214858-B1 | PREVENTING AND TREATING EXCESSIVE CELL DEATH USING OXINDOLE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION | 2001-04-10 | — | — | US | disclosed |