Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.30 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7444851 | 0.89 | AGTR1 (0.31) | TGFBR1AGTR1AGTR2 | |
| SCHEMBL7434477 | 0.84 | TGFBR1 (0.35) | TGFBR1AGTR1AGTR2 | |
| SCHEMBL7426716 | 0.83 | AGTR1 (0.34) | AGTR1 | |
| SCHEMBL7438414 | 0.82 | KDM4E (0.34) | TGFBR1KDM4EALDH1A1 | |
| SCHEMBL7442523 | 0.82 | HSP90AA1 (0.32) | TGFBR1 | |
| SCHEMBL7438523 | 0.81 | IDO1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL7440881 | 0.80 | AGTR1 (0.36) | AGTR1AGTR2 | |
| SCHEMBL7438209 | 0.80 | TSHR (0.53) | TSHRSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL7440524 | 0.80 | AGTR1 (0.41) | AGTR1AGTR2 | |
| SCHEMBL7443450 | 0.77 | RAB9A (0.35) | TSHRSMN1; SMN2AGTR1AGTR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |