Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7428732 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL10444057 | 0.77 | ACE (0.49) | — | |
| SCHEMBL10444059 | 0.77 | ACE (0.49) | — | |
| SCHEMBL10444056 | 0.75 | KLK5 (0.49) | L3MBTL1ALDH1A1 | |
| SCHEMBL30932891 | 0.74 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1HTTTP53HSD17B10 | |
| SCHEMBL10443376 | 0.74 | HTR1A (0.34) | ALDH1A1GAA | |
| SCHEMBL13594013 | 0.73 | SMN1; SMN2 (0.42) | SMN1; SMN2NAMPTL3MBTL1BRD4CREBBP | |
| SCHEMBL13978122 | 0.72 | HTR1A (0.40) | ALDH1A1HPGDGAA | |
| SCHEMBL19423686 | 0.72 | SMN1; SMN2 (0.44) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT | |
| SCHEMBL7438342 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2NAMPTL3MBTL1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0375451-A2 | Compounds having a renin-inhibiting activity | BEECHAM GROUP PLC (GB) | 1990-06-27 | — | — | EP | claimed |