Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PDE2A | O00408 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | DRD5 | P21918 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6051984 | 0.86 | HPGD (0.42) | HPGDALDH1A1USP2TSHRMEN1 | |
| SCHEMBL7449080 | 0.85 | ADORA2A (0.39) | HPGDALDH1A1USP2TSHRMEN1 | |
| SCHEMBL6051956 | 0.82 | PDE2A (0.43) | HPGDALDH1A1USP2TSHRMEN1 | |
| SCHEMBL7433401 | 0.82 | ALDH1A1 (0.40) | HPGDALDH1A1USP2TSHRMEN1 | |
| SCHEMBL7445158 | 0.80 | ALDH1A1 (0.40) | HPGDALDH1A1USP2TSHRMEN1 | |
| SCHEMBL7442320 | 0.78 | PDE2A (0.52) | ALDH1A1KMT2AADORA3PDE2A | |
| SCHEMBL7443226 | 0.78 | ADORA1 (0.39) | HPGDALDH1A1USP2TSHRMEN1 | |
| SCHEMBL359546 | 0.74 | PDE2A (0.51) | HPGDALDH1A1MAPK1TP53PDE2A | |
| SCHEMBL6023455 | 0.71 | PDE2A (0.43) | PDE2A | |
| SCHEMBL6024717 | 0.71 | PDE2A (0.46) | HPGDALDH1A1TSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6440981-B1 | REGULATING APOPTOSIS IN HUMAN CELLS COMPRISING EXPOSING SAID CELLS TO AN EFFECTIVE AMOUNT OF A 2,9-DISUBSTITUTED PURINE-6 ONE COMPOUND | CELL PATHWAYS, INC. | 2002-08-27 | — | — | US | disclosed |
| US-20020032209-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones | OSI PHARMACEUTICALS, INC. | 2002-03-14 | — | — | US | disclosed |
| US-6268372-B1 | Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones | CELL PATHWAYS, INC. | 2001-07-31 | — | — | US | disclosed |
| US-5861404-A | ANTIINFLAMMATORY AGENTS, THROMBOEMBOLIC AND CARDIOVASCULAR DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-01-19 | — | — | US | disclosed |
| EP-0722944-A1 | 2-9-Disubstituted Purin-6-ones | BAYER AG (DE) | 1996-07-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020032209-A1 | Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones | MKI67, PCNA, HRAS | HPGD 612/4885ALDH1A1 1111/4885USP2 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.