Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DHPS | P49366 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7434190 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAMAPTDHPS | |
| SCHEMBL7439974 | 0.77 | LMNA (0.46) | KMT2ALMNAGAAMAPK1 | |
| SCHEMBL25120814 | 0.76 | DHPS (0.57) | MAPTDHPSHPGDMAPK1 | |
| SCHEMBL4865366 | 0.74 | MAPK1 (0.56) | ALDH1A1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7849826 | 0.74 | DHPS (0.57) | DHPSMAPK1 | |
| SCHEMBL4107305 | 0.74 | KDM4E (0.66) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL4025098 | 0.73 | MAPK1 (0.63) | DHPSMAPK1 | |
| SCHEMBL29901215 | 0.73 | MAPK1 (0.63) | DHPSMAPK1 | |
| SCHEMBL13046884 | 0.72 | MAPK1 (0.61) | ALDH1A1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL257380 | 0.72 | MAPK1 (0.71) | ALDH1A1KDM4EDHPSGAAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1297439-A | 4-amino-(ethylamino)-oxindole dopamine autoreceptor agonists | AMERICAN HOME PROD (US) | 2001-05-30 | — | — | CN | disclosed |
| US-6228880-B1 | PARKINSON*S DISEASE, TOURETTE*S SYNDROME, SCHIZOPHRENIA, ALCOHOLISM, DRUG ABUSE; SIDE EFFECT REDUCTION | AMERICAN HOME PRODUCTS CORP | 2001-05-08 | — | — | US | disclosed |
| EP-1073636-A1 | 4-AMINO-(ETHYLAMINO)-OXINDOLE DOPAMINE AUTORECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-07 | — | — | EP | disclosed |
| WO-1999052870-A1 | 4-AMINO-(ETHYLAMINO)-OXINDOLE DOPAMINE AUTORECEPTOR AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-21 | — | — | WO | disclosed |