Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.59 |
| ▸ | ATP4A | P20648 | 4/20 | 0.56 |
| ▸ | ATP4B | P51164 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9485871 | 0.77 | HTR3A (0.65) | MEN1KMT2AATP4AATP4BMAPT | |
| SCHEMBL21788583 | 0.75 | MEN1 (1.00) | MEN1KMT2AATP4AATP4BMAPT | |
| SCHEMBL29906081 | 0.75 | MEN1 (1.00) | MEN1KMT2AATP4AATP4BMAPT | |
| SCHEMBL7441503 | 0.74 | ALDH1A1 (0.58) | MEN1KMT2AATP4AATP4BMAPT | |
| Bromide SCHEMBL27136693 | 0.74 | MEN1 (0.97) | MEN1KMT2AATP4AATP4BMAPT | |
| SCHEMBL7443407 | 0.70 | NPC1 (0.56) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL7431740 | 0.70 | ATP4A (0.54) | MEN1KMT2AATP4AATP4BMAPT | |
| SCHEMBL15125584 | 0.67 | ALDH1A1 (0.46) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL31477980 | 0.67 | MEN1 (0.65) | MEN1KMT2AATP4AATP4BMAPT | |
| SCHEMBL30693693 | 0.67 | POLB (0.71) | MEN1KMT2AATP4AATP4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397364-B1 | HETEROCYCLIC GUANIDINES AS 5HT 3 ANTAGONISTS | PFIZER INC. (US) | 1993-07-28 | — | — | EP | claimed |
| EP-0397364-A1 | Heterocyclic guanidines AS 5HT 3 Antagonists | PFIZER INC. (US) | 1990-11-14 | — | — | EP | claimed |
| EP-0397364-B1 | HETEROCYCLIC GUANIDINES AS 5HT 3 ANTAGONISTS | PFIZER INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0397364-A1 | Heterocyclic guanidines AS 5HT 3 Antagonists | PFIZER INC. (US) | 1990-11-14 | — | — | EP | disclosed |
| US-4963689-A | ANTIEMETICS, ANALGESICS, GASTROINTESTINAL DISORDERS, SCHIZOPHRENIA | PFIZER INC. (US) | 1990-10-16 | — | — | US | disclosed |