Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12963165 | 0.86 | — | — | |
| SCHEMBL11512895 | 0.77 | — | — | |
| SCHEMBL9544521 | 0.76 | EPHX1 (0.34) | ALDH1A1EPHX1THRBDNM1 | |
| SCHEMBL4235668 | 0.76 | — | — | |
| SCHEMBL30710203 | 0.74 | THRB (0.48) | ALDH1A1EPHX1THRBDNM1 | |
| SCHEMBL13758598 | 0.74 | DNM1 (0.31) | ALDH1A1DNM1 | |
| SCHEMBL1472438 | 0.74 | THRB (0.48) | ALDH1A1EPHX1THRBDNM1 | |
| SCHEMBL2101563 | 0.72 | EPHX1 (0.41) | ALDH1A1EPHX1THRBDNM1 | |
| Bromide SCHEMBL9480946 | 0.72 | DNM1 (0.30) | ALDH1A1DNM1 | |
| SCHEMBL20145830 | 0.71 | ALDH1A1 (0.39) | ALDH1A1EPHX1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0873311-A1 | TRI-ARYL ETHANE DERIVATIVES AS PDE IV INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-10-28 | — | — | EP | disclosed |
| EP-0873310-A1 | DIPHENYL PYRIDYL ETHANE DERIVATIVES AS PDE IV INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1998-10-28 | — | — | EP | disclosed |
| US-5710160-A | PHOSPHODIESTERASE IV INHIBITORS FOR TREATMENT OF ASTHMA BY RAISING LEVELS OF CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | disclosed |
| US-5710170-A | Tri-aryl ethane derivatives as PDE IV inhibitors | MERCK FROSST CANADA, INC. (CA) | 1998-01-20 | — | — | US | disclosed |
| WO-1997022585-A1 | DIPHENYL PYRIDYL ETHANE DERIVATIVES AS PDE IV INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-06-26 | — | — | WO | disclosed |
| WO-1997022586-A1 | TRI-ARYL ETHANE DERIVATIVES AS PDE IV INHIBITORS | MERCK FROSST CANADA INC. (CA) | 1997-06-26 | — | — | WO | disclosed |