Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 4/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 4/20 | 0.39 |
| ▸ | NQO2 | P16083 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.33 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | TTR | P02766 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.33 |
| ▸ | TUBB | P07437 | 1/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261556 | 0.85 | ALDH1A1 (0.53) | ALDH1A1CYP1A1CYP1B1NQO2TAAR1 | |
| SCHEMBL19724 | 0.83 | ALDH1A1 (0.56) | ALDH1A1CYP1A1CYP1B1NQO2CYP1A2 | |
| SCHEMBL261996 | 0.79 | NQO2 (0.31) | NQO2NFE2L2TUBB4ATUBBTUBA3C | |
| SCHEMBL386286 | 0.77 | ACHE (0.39) | — | |
| SCHEMBL491166 | 0.76 | ALDH1A1 (0.48) | ALDH1A1CYP1A1CYP1B1NQO2TAAR1 | |
| SCHEMBL2342604 | 0.76 | AHR (0.33) | AHR | |
| SCHEMBL2347097 | 0.76 | ALDH1A1 (0.42) | ALDH1A1CYP1A1CYP1B1NQO2TAAR1 | |
| SCHEMBL15353271 | 0.76 | HSD17B10 (0.32) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9444304 | 0.73 | ALDH1A1 (0.43) | ALDH1A1CYP1A1CYP1B1NQO2TAAR1 | |
| SCHEMBL9444407 | 0.73 | ALDH1A1 (0.43) | ALDH1A1CYP1A1CYP1B1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100371361-C | Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions | ATOFINA CHEM INC (US) | 2008-02-27 | — | — | CN | claimed |
| US-9242970-B2 | Lactam derivatives useful as orexin receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-01-26 | — | — | US | disclosed |
| EP-2638008-B1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2015-07-01 | — | — | EP | disclosed |
| EP-2638008-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2013-09-18 | — | — | EP | disclosed |
| US-20130237525-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2013-09-12 | — | — | US | disclosed |
| EP-2430004-B1 | NOVEL OXAZOLIDINONE DERIVATIVES AND THEIR USE AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2013-07-17 | — | — | EP | disclosed |
| US-8329706-B2 | Oxazolidinone derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-12-11 | — | — | US | disclosed |
| WO-2012063207-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-05-18 | — | — | WO | disclosed |
| US-20120101111-A1 | NOVEL OXAZOLIDINONE DERIVIATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2012-04-26 | — | — | US | disclosed |
| US-20120088759-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-04-12 | — | — | US | disclosed |
| EP-1479737-B1 | Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions | ARKEMA INC (US) | 2006-08-16 | — | — | EP | disclosed |
| EP-1554258-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2005-07-20 | — | — | EP | disclosed |
| CN-1618828-A | Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions | ATOFINA CHEM INC (US) | 2005-05-25 | — | — | CN | disclosed |
| EP-1479737-A1 | Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions | Atofina Chemicals, Inc. (US) | 2004-11-24 | — | — | EP | disclosed |
| US-20040138332-A1 | Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions | ARKEMA INC. | 2004-07-15 | — | — | US | disclosed |
| US-20040106620-A1 | 5-Substituted-2-arylpyrazines | NEUROGEN CORPORATION | 2004-06-03 | — | — | US | disclosed |
| CN-1488694-A | Polymer for ship coating-composition containing diarye silyl (methye) acroyl | ���з��ɻ�ѧ�ɷ�����˾ | 2004-04-14 | — | — | CN | disclosed |
| WO-2004018437-A1 | 5-SUBSTITUTED-2-ARYLPYRAZINES AS MODULATORS OF CRF RECEPTORS | NEUROGEN CORPORATION (US) | 2004-03-04 | — | — | WO | disclosed |
| US-20030225184-A1 | Triarylsilyl(meth)acryloyl-containing polymers for marine coating compositions | ARKEMA INC. | 2003-12-04 | — | — | US | disclosed |
| EP-1367100-A1 | Triarylsilyl (meth) acryloyl-containing polymers for marine coating compositions | ATOFINA CHEMICALS, INC. (US) | 2003-12-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120101111-A1 | NOVEL OXAZOLIDINONE DERIVIATIVES | HCRTR2, HCRTR1, NPY4R | ALDH1A1 715/4885CYP1A1 366/4885CYP1B1 261/4885 |
| US-20040106620-A1 | 5-Substituted-2-arylpyrazines | HTR5A, CRHR2, HTR2C | ALDH1A1 2442/4885CYP1A1 2976/4885CYP1B1 3434/4885 |
| US-20130237525-A1 | LACTAM DERIVATIVES USEFUL AS OREXIN RECEPTOR ANTAGONISTS | HCRTR2, HCRTR1, NPY1R | ALDH1A1 2282/4885CYP1A1 720/4885CYP1B1 558/4885 |
| US-20120088759-A1 | THIAZOLIDIN-4-ONE AND [1,3]-THIAZINAN-4-ONE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS | HCRTR1, HCRTR2, NPY4R | ALDH1A1 942/4885CYP1A1 773/4885CYP1B1 725/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.