Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 3/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24320056 | 0.81 | TDP1 (0.44) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL6036699 | 0.80 | ALDH1A1 (0.47) | LMNAMAPTALDH1A1TDP1TSHR | |
| SCHEMBL11644545 | 0.80 | LMNA (0.56) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL6137884 | 0.79 | LMNA (0.51) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL7447014 | 0.79 | TDP1 (0.51) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL2337048 | 0.78 | POLB (0.47) | LMNAMAPTALDH1A1TDP1MAPK1 | |
| SCHEMBL9206967 | 0.78 | TSHR (0.44) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL9206958 | 0.78 | TSHR (0.44) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL28842313 | 0.78 | TDP1 (0.50) | LMNAMAPTALDH1A1TDP1L3MBTL1 | |
| SCHEMBL6834458 | 0.77 | ALDH1A1 (0.45) | LMNAMAPTALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741715-B1 | NOVEL HUMAN LEUKOCYTE ELASTASE (HLE) INHIBITORS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | STANFORD RES INST INT (US) | 1998-08-26 | — | — | EP | disclosed |
| EP-0741715-A1 | NOVEL HUMAN LEUKOCYTE ELASTASE (HLE) INHIBITORS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020581-A1 | NOVEL HUMAN LEUKOCYTE ELASTASE (HLE) INHIBITORS, AND RELATED PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | SRI INTERNATIONAL (US) | 1995-08-03 | — | — | WO | disclosed |
| US-5428021-A | Administering to inhibit serine proteases | SRI INTERNATIONAL (US) | 1995-06-27 | — | — | US | disclosed |