SCHEMBL744433

SCHEMBL744433

C=CCCCC1=CC(=C(c2ccccc2)c2ccccc2)C=C1

nearest known ligand 0.32

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.32
ALDH1A1 P00352 2/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
TDP1 Q9NUW8 2/20 0.31
HDAC6 Q9UBN7 1/20 0.31
GPR52 Q9Y2T5 1/20 0.30
USP2 O75604 1/20 0.30
HPGD P15428 1/20 0.30
AKT1 P31749 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL743416 0.91 TDP1 (0.32) ALDH1A1TDP1HDAC6HPGDAKT1
SCHEMBL741534 0.70 TDP1 (0.34) TDP1HDAC6
SCHEMBL744432 0.69 ALDH1A1 (0.33) TLR8ALDH1A1L3MBTL1TDP1USP2
SCHEMBL7029068 0.68 ALDH1A1 (0.31) ALDH1A1TDP1USP2HPGD
SCHEMBL4387095 0.67 L3MBTL1 (0.34) ALDH1A1L3MBTL1TDP1HPGDAKT1
SCHEMBL20521131 0.66 MAPT (0.38) ALDH1A1L3MBTL1TDP1HDAC6USP2
SCHEMBL28870170 0.65 TDP1 (0.32) TDP1HDAC6
SCHEMBL106849 0.65 SIGMAR1 (0.48) ALDH1A1HDAC6HPGD
Ammonia Solution, Strong SCHEMBL10647609 0.63 SIGMAR1 (0.46) ALDH1A1HDAC6HPGD
SCHEMBL10585025 0.63 SIGMAR1 (0.51)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3239190-B1 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL CO LP (US) 2020-01-29 EP disclosed
EP-3239190-A2 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING Chevron Phillips Chemical Company LP (US) 2017-11-01 EP disclosed
EP-1984408-B1 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL CO LP (US) 2017-07-26 EP disclosed
US-8268944-B2 Dual metallocene catalysts for polymerization of bimodal polymers Chevron Phillips Company, L.P. (US) 2012-09-18 US disclosed
US-20120190804-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-07-26 US disclosed
US-8138113-B2 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-03-20 US disclosed
US-20110201770-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-08-18 US disclosed
US-7960487-B2 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-06-14 US disclosed
US-7732542-B2 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2010-06-08 US disclosed
US-20100069582-A1 POLYMERIZATION CATALYSTS FOR PRODUCING HIGH MOLECULAR WEIGHT POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2010-03-18 US disclosed
US-7652160-B2 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching Cheveron Phillips Chemical Company, L.P. (US) 2010-01-26 US disclosed
US-7619047-B2 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2009-11-17 US disclosed
US-20090281342-A1 POLYMERIZATION CATALYSTS FOR PRODUCING HIGH MOLECULAR WEIGHT POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL COMPANY, LP 2009-11-12 US disclosed
US-7517939-B2 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2009-04-14 US disclosed
EP-1989238-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS Chevron Phillips Chemical Company LP (US) 2008-11-12 EP disclosed
EP-1984408-A2 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING Chevron Phillips Chemical Company LP (US) 2008-10-29 EP disclosed
WO-2007101053-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2007-09-07 WO disclosed
US-20070197374-A1 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. 2007-08-23 US disclosed
WO-2007092753-A2 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2007-08-16 WO disclosed
US-20070179044-A1 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. 2007-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281342-A1 POLYMERIZATION CATALYSTS FOR PRODUCING HIGH MOLECULAR WEIGHT POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING PARG, PARP1, PCNA TLR8 3368/4885ALDH1A1 3078/4885L3MBTL1 2427/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.