SCHEMBL741534

SCHEMBL741534

C=CCCC(C)(C)C1=CC(=C(c2ccccc2)c2ccccc2)C=C1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.34
HDAC6 Q9UBN7 1/20 0.34
HSP90AA1 P07900 2/20 0.30
HSP90AB1 P08238 1/20 0.30
MAPT P10636 1/20 0.30
TLR9 Q9NR96 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2274381 0.75 TDP1 (0.39) TDP1HDAC6HSP90AA1MAPTTLR9
SCHEMBL743416 0.72 TDP1 (0.32) TDP1HDAC6
SCHEMBL744433 0.70 TLR8 (0.32) TDP1HDAC6
SCHEMBL10865897 0.68 TAAR1 (0.48) MAPT
SCHEMBL7905899 0.64 SRC (0.41) TDP1HSP90AA1HSP90AB1MAPT
SCHEMBL8236361 0.63 CYP2C19 (0.36) HSP90AA1HSP90AB1MAPT
SCHEMBL5086744 0.63 MEN1 (0.41) TDP1HDAC6HSP90AA1MAPTTLR9
SCHEMBL28831712 0.62 ALDH1A1 (0.42) HSP90AA1HSP90AB1MAPT
SCHEMBL9317928 0.61 MAPK1 (0.41) MAPT
SCHEMBL5083754 0.61 TDP1 (0.35) TDP1HDAC6HSP90AA1TLR9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3239190-B1 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL CO LP (US) 2020-01-29 EP disclosed
EP-3239190-A2 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING Chevron Phillips Chemical Company LP (US) 2017-11-01 EP disclosed
EP-1984408-B1 POLYMERIZATION CATALYSTS FOR PRODUCING POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL CO LP (US) 2017-07-26 EP disclosed
US-8268944-B2 Dual metallocene catalysts for polymerization of bimodal polymers Chevron Phillips Company, L.P. (US) 2012-09-18 US disclosed
US-20120190804-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-07-26 US disclosed
US-8138113-B2 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2012-03-20 US disclosed
US-20110201770-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-08-18 US disclosed
US-7960487-B2 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2011-06-14 US disclosed
US-7732542-B2 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2010-06-08 US disclosed
US-20100069582-A1 POLYMERIZATION CATALYSTS FOR PRODUCING HIGH MOLECULAR WEIGHT POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2010-03-18 US disclosed
US-20100041842-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2010-02-18 US disclosed
US-7652160-B2 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching Cheveron Phillips Chemical Company, L.P. (US) 2010-01-26 US disclosed
US-7619047-B2 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2009-11-17 US disclosed
US-20090281342-A1 POLYMERIZATION CATALYSTS FOR PRODUCING HIGH MOLECULAR WEIGHT POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING CHEVRON PHILLIPS CHEMICAL COMPANY, LP 2009-11-12 US disclosed
US-7517939-B2 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching CHEVRON PHILLIPS CHEMICAL COMPANY, LP (US) 2009-04-14 US disclosed
EP-1989238-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS Chevron Phillips Chemical Company LP (US) 2008-11-12 EP disclosed
WO-2007101053-A1 DUAL METALLOCENE CATALYSTS FOR POLYMERIZATION OF BIMODAL POLYMERS CHEVRON PHILLIPS CHEMICAL COMPANY LP (US) 2007-09-07 WO disclosed
US-20070197374-A1 Dual metallocene catalysts for polymerization of bimodal polymers CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. 2007-08-23 US disclosed
US-20070179044-A1 Polymerization catalysts for producing high molecular weight polymers with low levels of long chain branching CHEVRON PHILLIPS CHEMICAL COMPANY, L.P. 2007-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090281342-A1 POLYMERIZATION CATALYSTS FOR PRODUCING HIGH MOLECULAR WEIGHT POLYMERS WITH LOW LEVELS OF LONG CHAIN BRANCHING PARG, PARP1, PCNA TDP1 3132/4885HDAC6 2200/4885HSP90AA1 3895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.