Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | MMP1 | P03956 | 2/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
| ▸ | MMP8 | P22894 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | F2 | P00734 | 3/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.37 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.37 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447633 | 0.90 | CA2 (0.43) | CA2CA1MMP1MMP2MMP9 | |
| Perflenapent SCHEMBL14763328 | 0.81 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL9505503 | 0.81 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| Perflexane SCHEMBL3192336 | 0.81 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL474710 | 0.81 | CA2 (0.52) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL14471986 | 0.79 | CA2 (0.35) | CA2CA1MMP1MMP2MMP9 | |
| Perflubutane SCHEMBL73685 | 0.77 | CA2 (0.48) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL302264 | 0.77 | CA2 (0.56) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL584864 | 0.77 | CA2 (0.56) | CA2CA1MMP1MMP2MMP9 | |
| SCHEMBL8634331 | 0.77 | CA2 (0.44) | CA2CA1MMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6034215-A | 3-amino-2-oxo-1-piperidnercetic derivatives as enzyme inhibitors | CORVAS INTERNATIONAL, INC. (US) | 2000-03-07 | — | — | US | disclosed |
| EP-0802923-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-10-29 | — | — | EP | disclosed |
| EP-0765339-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES CONTAINING AN ARGININE MIMIC AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1997-04-02 | — | — | EP | disclosed |
| WO-1995035311-A9 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | — | 1996-02-01 | — | — | WO | disclosed |
| WO-1995035313-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES CONTAINING AN ARGININE MIMIC AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |
| WO-1995035311-A1 | 3-AMINO-2-OXO-1-PIPERIDINEACETIC DERIVATIVES AS ENZYME INHIBITORS | CORVAS INTERNATIONAL, INC. (US) | 1995-12-28 | — | — | WO | disclosed |