Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD3 | Q15059 | 2/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7448066 | 0.81 | CCNT1 (0.34) | BRD3CCNT1CDK9TLR8TLR7 | |
| SCHEMBL7453129 | 0.80 | HTR6 (0.41) | BRD3CCNT1CDK9TLR8TLR7 | |
| SCHEMBL4674696 | 0.76 | SCN9A (0.44) | BRD3GPR119SMN1; SMN2PLK1LMNA | |
| SCHEMBL24330047 | 0.73 | BRD3 (0.51) | BRD3SMN1; SMN2PLK1 | |
| SCHEMBL2567932 | 0.72 | CCR3 (0.53) | BRD3GPR119SMN1; SMN2 | |
| SCHEMBL4674153 | 0.72 | HSD11B1 (0.60) | BRD3 | |
| SCHEMBL1299150 | 0.71 | SMN1; SMN2 (0.52) | BRD3SMN1; SMN2LMNA | |
| SCHEMBL4774609 | 0.69 | OPRM1 (0.54) | BRD3SMN1; SMN2TLR8TLR7LMNA | |
| SCHEMBL5726423 | 0.68 | BRD3 (0.55) | BRD3GPR119 | |
| SCHEMBL8296791 | 0.68 | HSD11B1 (0.66) | BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |