Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.40 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.34 |
| ▸ | CDK9 | P50750 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442844 | 0.85 | HTR6 (0.40) | HTR6TLR9TLR8TLR7SLC6A4 | |
| SCHEMBL7448066 | 0.83 | CCNT1 (0.34) | TLR9TLR8TLR7BRD3HTR2A | |
| SCHEMBL7444565 | 0.80 | BRD3 (0.50) | TLR8TLR7BRD3CCNT1CDK9 | |
| SCHEMBL373751 | 0.72 | HTR6 (0.69) | HTR6TLR9TLR8TLR7BRD3 | |
| SCHEMBL4670567 | 0.69 | HTR6 (0.61) | HTR6SLC6A4KCNH2 | |
| SCHEMBL7450455 | 0.66 | HTR6 (0.40) | HTR6TLR9TLR8TLR7SLC6A4 | |
| Sulfamate SCHEMBL27480106 | 0.66 | HTR6 (0.56) | HTR6SLC6A4KCNH2 | |
| SCHEMBL4078326 | 0.62 | PARP1 (0.48) | HTR6TLR9TLR8TLR7SLC6A4 | |
| SCHEMBL2567532 | 0.62 | HTR6 (0.58) | HTR6HTR2AHTR2CKCNH2 | |
| SCHEMBL24330059 | 0.61 | HTR2A (0.47) | BRD3SLC6A4HTR2AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |