Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.34 |
| ▸ | KCNN3 | Q9UGI6 | 4/20 | 0.33 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.32 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.31 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442336 | 0.87 | KCNN3 (0.45) | KCNN3MAPKAPK2KCNN1KCNN2DPP4 | |
| SCHEMBL7440794 | 0.85 | MEN1 (0.39) | KCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL7447901 | 0.85 | AGTR1 (0.41) | KCNN3MAPKAPK2KCNN1KCNN2CDK2 | |
| SCHEMBL7433866 | 0.83 | PDE10A (0.38) | KCNN3MAPKAPK2KCNN1KCNN2DPP4 | |
| SCHEMBL7442347 | 0.80 | DPP4 (0.40) | DPP4 | |
| SCHEMBL7437181 | 0.79 | PKM (0.34) | KCNN3 | |
| SCHEMBL7432932 | 0.78 | MAPT (0.36) | — | |
| SCHEMBL7441328 | 0.73 | KCNN3 (0.62) | KCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL7440984 | 0.73 | AGTR1 (0.51) | KCNN3KCNN1KCNN2CDK2 | |
| SCHEMBL7438720 | 0.72 | KCNN3 (0.47) | KCNN3KCNN1KCNN2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |