Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297001 | 0.87 | ALDH1A1 (0.53) | ALDH1A1MAPTKMT2ALMNANPC1 | |
| SCHEMBL7445245 | 0.79 | ALDH1A1 (0.57) | ALDH1A1KMT2ALMNACYP2C19GAA | |
| SCHEMBL31479993 | 0.76 | ALDH1A1 (0.51) | ALDH1A1KMT2ALMNAOPRD1GAA | |
| SCHEMBL27615561 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KMT2ALMNA | |
| SCHEMBL11272120 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KMT2ALMNANPC1GLA | |
| SCHEMBL8922653 | 0.73 | ALDH1A1 (0.54) | ALDH1A1MAPTKMT2ALMNAOPRM1 | |
| SCHEMBL7445267 | 0.73 | MLYCD (0.55) | ALDH1A1KMT2ALMNAOPRM1OPRD1 | |
| SCHEMBL321369 | 0.72 | ALDH1A1 (1.00) | ALDH1A1MAPTKMT2ALMNACYP2C19 | |
| SCHEMBL22858397 | 0.72 | ALDH1A1 (0.55) | ALDH1A1MAPTKMT2ALMNACYP2C19 | |
| SCHEMBL20421705 | 0.72 | ALDH1A1 (0.53) | ALDH1A1KMT2ALMNANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817795-B1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | NAEJA PHARMACEUTICAL INC (CA) | 2000-11-15 | — | — | EP | disclosed |
| US-5986108-A | ENZYME INHIBITORS | SYNPHAR LABORATORIES, INC. (CA) | 1999-11-16 | — | — | US | disclosed |
| EP-0817795-A1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | SYNPHAR LABORATORIES INC. (CA) | 1998-01-14 | — | — | EP | disclosed |
| WO-1996032408-A1 | NOVEL 4-SUBSTITUTED-3-PEPTIDYL-AZETIDIN-2-ONE DERIVATIVES USEFUL AS CYSTEINE PROTEINASE INHIBITOR | SYNPHAR LABORATORIES, INC. (US) | 1996-10-17 | — | — | WO | disclosed |