Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8096459 | 0.74 | MEN1 (0.49) | MMP14ADAMTS5MAPTMEN1KMT2A | |
| SCHEMBL4673959 | 0.73 | GRM5 (0.41) | GRM5MMP14ADAMTS5POLBMAPT | |
| SCHEMBL8109659 | 0.71 | MEN1 (0.52) | MMP14ADAMTS5POLBMAPTMEN1 | |
| SCHEMBL4673787 | 0.69 | MMP2 (0.64) | MMP14 | |
| SCHEMBL4673790 | 0.69 | MMP2 (0.64) | MMP14 | |
| SCHEMBL4675059 | 0.69 | RORC (0.48) | GRM5MAPTMEN1KMT2ATP53 | |
| SCHEMBL4675062 | 0.69 | RORC (0.48) | GRM5MAPTMEN1KMT2ATP53 | |
| SCHEMBL7448674 | 0.68 | MAPT (0.53) | MMP14ADAMTS5POLBMAPTMEN1 | |
| SCHEMBL4673538 | 0.67 | MMP2 (0.55) | GRM5MMP14ADAMTS5POLBMAPT | |
| SCHEMBL4673540 | 0.67 | MMP2 (0.55) | GRM5MMP14ADAMTS5POLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958287-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998032748-A1 | SULFAMIDE-METALLOPROTEASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-07-30 | — | — | WO | disclosed |