Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | PGR | P06401 | 7/20 | 0.47 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CCR4 | P51679 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 2/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367213 | 0.88 | MAOB (0.64) | POLBMAOBPGRHAVCR2KDM4E | |
| SCHEMBL30930127 | 0.88 | MAOB (0.64) | POLBMAOBPGRHAVCR2KDM4E | |
| SCHEMBL9741963 | 0.85 | KDM4E (0.43) | POLBHAVCR2KDM4EGAAALDH1A1 | |
| SCHEMBL8950204 | 0.81 | ABCB1 (0.41) | POLBPGRGAAMEN1ALDH1A1 | |
| SCHEMBL12793653 | 0.79 | POLB (0.62) | POLBMAOBPGRALDH1A1MAPT | |
| SCHEMBL8349538 | 0.79 | POLB (0.62) | POLBMAOBPGRALDH1A1MAPT | |
| SCHEMBL1857924 | 0.79 | LMNA (0.57) | MAOBKDM4EMEN1ALDH1A1MAPT | |
| SCHEMBL7371675 | 0.78 | MAPT (0.67) | POLBMAOBPGRHAVCR2MEN1 | |
| SCHEMBL4084714 | 0.78 | PGR (0.64) | POLBMAOBPGRALDH1A1MAPT | |
| SCHEMBL24815335 | 0.77 | POLB (0.64) | POLBPGRKDM4EGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1994000454-A1 | BENZIMIDAZOLE COMPOUNDS | G.D. SEARLE & CO. (US) | 1994-01-06 | — | — | WO | disclosed |