Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8950333 | 0.83 | MAPT (0.45) | HCAR3MEN1KMT2APGRMAPT | |
| SCHEMBL7362765 | 0.81 | HCAR3 (0.58) | ABCB1ABCC1HCAR3RAB9AMEN1 | |
| SCHEMBL7445525 | 0.81 | POLB (0.57) | MEN1KMT2APGRMAPTALDH1A1 | |
| SCHEMBL25403172 | 0.71 | PGR (0.63) | MEN1KMT2APGRALDH1A1POLB | |
| SCHEMBL3322365 | 0.71 | MAPT (0.56) | RAB9AMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL8950320 | 0.71 | PGR (0.50) | PGRMAPTPOLB | |
| SCHEMBL9742270 | 0.71 | MAPT (0.56) | ABCB1ABCC1HCAR3RAB9AMEN1 | |
| SCHEMBL30930127 | 0.71 | MAOB (0.64) | MEN1KMT2APGRMAPTALDH1A1 | |
| SCHEMBL7367213 | 0.71 | MAOB (0.64) | MEN1KMT2APGRMAPTALDH1A1 | |
| SCHEMBL9741963 | 0.69 | KDM4E (0.43) | MAPTTHRBALDH1A1GAAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5534521-A | SEROTONIN ANTAGONISTS | G. D. SEARLE & CO. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5521193-A | SEROTONIN AGONISTS AND ANTAGONISTS | G. D. SEARLE & CO. (US) | 1996-05-28 | — | — | US | disclosed |