SCHEMBL7445552

SCHEMBL7445552

CC1(C)OC(=O)N(C2CCNCC2)c2ccccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNKS O95271 2/20 0.43
HTR2C P28335 8/20 0.37
HTR2A P28223 4/20 0.37
HTR2B P41595 5/20 0.36
DHODH Q02127 1/20 0.36
NOTUM Q6P988 1/20 0.35
NSD3 Q9BZ95 1/20 0.34
OXTR P30559 2/20 0.34
PRKCG P05129 1/20 0.33
PRKCB P05771 1/20 0.33
PRKCA P17252 1/20 0.33
PRKCH P24723 1/20 0.33
PRKCE Q02156 1/20 0.33
PRKCZ Q05513 1/20 0.33
PRKCD Q05655 1/20 0.33
CAMK2B Q13554 1/20 0.33
CAMK2G Q13555 1/20 0.33
CAMK2D Q13557 1/20 0.33
CAMK2A Q9UQM7 1/20 0.33
PARP1 P09874 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4042073 0.82 SIGMAR1 (0.39) TNKSHTR2CHTR2AHTR2BDHODH
SCHEMBL30778913 0.79 TNKS (0.46) TNKSHTR2CHTR2AHTR2BNSD3
Hydrochloric Acid SCHEMBL181819 0.78 TNKS (0.45) TNKSHTR2CHTR2AHTR2BALDH1A1
SCHEMBL7485022 0.77 GPR119 (0.46) PRKCGPRKCBPRKCAPRKCHPRKCE
Hydrochloric Acid SCHEMBL4042152 0.74 OPRM1 (0.46) TNKSDHODH
SCHEMBL4037787 0.74 OPRM1 (0.37) TNKSHTR2CHTR2AHTR2BNOTUM
SCHEMBL1815815 0.73 TNKS (0.54) TNKSHTR2CHTR2AHTR2BNOTUM
SCHEMBL5112591 0.73 OPRM1 (0.38) TNKSHTR2CHTR2AHTR2BDHODH
SCHEMBL4035221 0.72 OPRM1 (0.36) TNKSHTR2CHTR2AHTR2BDHODH
SCHEMBL10063517 0.71 OPRL1 (0.41) TNKSHTR2CHTR2AHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0714299-B1 BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 2002-04-24 EP disclosed
US-5665719-A Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists MERCK & CO., INC. (US) 1997-09-09 US disclosed
EP-0714299-A4 1996-07-10 EP disclosed
EP-0714299-A1 BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1996-06-05 EP disclosed
WO-1995002405-A1 BENZOXAZINONE AND BENZOPYRIMIDINONE PIPERIDINYL TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1995-01-26 WO disclosed