Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | LTA4H | P09960 | 4/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.52 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768025 | 0.87 | MCHR1 (0.51) | HRH3KCNH2LTA4HMCHR1ESR1 | |
| SCHEMBL7441443 | 0.85 | ESR1 (0.56) | HRH3KCNH2LTA4HESR1ESR2 | |
| SCHEMBL7768257 | 0.83 | ESR1 (0.56) | POLBHRH3KCNH2LTA4HESR1 | |
| SCHEMBL6594650 | 0.81 | LTA4H (0.60) | HRH3LTA4H | |
| SCHEMBL6593929 | 0.81 | ESR1 (0.56) | HRH3LTA4HESR1ESR2 | |
| SCHEMBL6595152 | 0.81 | LTA4H (0.55) | HRH3LTA4HESR1ESR2 | |
| SCHEMBL6597298 | 0.76 | ACHE (0.54) | HRH3LTA4HESR1ESR2CHEK1 | |
| SCHEMBL7774143 | 0.76 | LTA4H (0.55) | HRH3LTA4HMCHR1ESR1ESR2 | |
| SCHEMBL6605680 | 0.76 | LTA4H (0.55) | HRH3KCNH2LTA4HMCHR1 | |
| SCHEMBL6955456 | 0.74 | LTA4H (0.72) | HRH3KCNH2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265575-B1 | THROMBIN INHIBITORS | ELI LILLY AND COMPANY | 2001-07-24 | — | — | US | disclosed |
| US-6251921-B1 | ADMINISTERING THROMBIN INHIBITING DIAMINE COMPOUND TO MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| US-6025382-A | Antithrombotic diamines | ELI LILLY AND COMPANY (US) | 2000-02-15 | — | — | US | disclosed |
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |