Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 2/20 | 0.31 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.31 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6499230 | 0.79 | SRD5A2 (0.49) | ADRA2AADRA2BADRA2CSRD5A2F2 | |
| SCHEMBL5450128 | 0.72 | KMT2A (0.33) | ADRA2AADRA2BSCN1ASCN2ASCN3A | |
| SCHEMBL7438313 | 0.72 | SLC6A2 (0.40) | — | |
| SCHEMBL7355498 | 0.70 | SRD5A2 (0.41) | ADRA2AADRA2BADRA2CSRD5A2F2 | |
| SCHEMBL7465279 | 0.70 | SRD5A2 (0.41) | ADRA2AADRA2BADRA2CSRD5A2F2 | |
| SCHEMBL8091536 | 0.70 | ALDH1A1 (0.32) | — | |
| SCHEMBL7448082 | 0.69 | SLC6A2 (0.40) | — | |
| SCHEMBL7510243 | 0.68 | KMT2A (0.44) | F2 | |
| SCHEMBL11531757 | 0.68 | KMT2A (0.35) | F2 | |
| SCHEMBL4575599 | 0.68 | IDO1 (0.43) | ADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628559-B1 | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF LILLY GMBH (DE) | 2002-04-03 | — | — | EP | disclosed |
| US-5602136-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5602137-A | Pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1997-02-11 | — | — | US | disclosed |
| US-5571813-A | Fused pyrimidine compounds and their use as pharmaceuticals | BEIERSDORF-LILLY GMBH (DE) | 1996-11-05 | — | — | US | disclosed |
| EP-0628559-A1 | Pyrimidine compounds and their use as pharmaceuticals | Beiersdorf-Lilly GmbH (DE) | 1994-12-14 | — | — | EP | disclosed |