Acetic Acid

Acetic Acid

SCHEMBL7445844

CC(=O)O.OCCCC1CCNCC1

nearest known ligand 0.46

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Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ITGB3 P05106 8/20 0.46
ITGA2B P08514 8/20 0.46
GABRA5 P31644 3/20 0.41
GABRB2 P47870 3/20 0.41
SLC6A1 P30531 2/20 0.41
SLC6A12 P48065 2/20 0.41
SLC6A11 P48066 2/20 0.41
SLC6A13 Q9NSD5 2/20 0.41
GABRA1 P14867 2/20 0.41
GABRA4 P48169 2/20 0.41
GABRR1 P24046 1/20 0.41
GNAI3 P08754 1/20 0.41
GNAO1 P09471 1/20 0.41
GNAI1 P63096 1/20 0.41
FAAH O00519 1/20 0.40
ALOX15 P16050 1/20 0.40
CPN1 P15169 1/20 0.40
CPB2 Q96IY4 1/20 0.40
GABRP O00591 1/20 0.39
GABRD O14764 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL5764925 0.88 GABRA5 (0.44) ITGB3ITGA2BGABRA5GABRB2SLC6A1
SCHEMBL28893 0.88 ITGB3 (0.42) ITGB3ITGA2BGABRA5GABRB2SLC6A1
Hydrochloric Acid SCHEMBL146163 0.86 ITGB3 (0.41) ITGB3ITGA2BGABRA5GABRB2SLC6A1
Bromide SCHEMBL11261498 0.86 ITGB3 (0.41) ITGB3ITGA2BGABRA5GABRB2SLC6A1
Acetic Acid SCHEMBL27909150 0.83 GNAO1 (0.54) ITGB3ITGA2BGNAI3GNAO1GNAI1
Acetic Acid SCHEMBL29252307 0.81 GNAO1 (0.56) ITGB3ITGA2BGNAI3GNAO1GNAI1
Acetic Acid SCHEMBL27704123 0.81 GABRA5 (0.48) ITGB3ITGA2BGABRA5GABRB2SLC6A1
SCHEMBL2544949 0.81 ITGB3 (0.41) ITGB3ITGA2BGABRA5GABRB2SLC6A1
Hydrochloric Acid SCHEMBL1844095 0.79 ITGB3 (0.40) ITGB3ITGA2BGABRA5GABRB2SLC6A1
SCHEMBL11261846 0.79 ITGB3 (0.40) ITGB3ITGA2BGABRA5GABRB2SLC6A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5786373-A Fibrinogen receptor antagonists MERCK & CO., INC. (US) 1998-07-28 US disclosed
EP-0667773-A4 FIBRINOGEN RECEPTOR ANTAGONISTS. MERCK & CO INC (US) 1996-09-25 EP disclosed
EP-0667773-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO. INC. (US) 1995-08-23 EP disclosed
WO-1994008577-A1 FIBRINOGEN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1994-04-28 WO disclosed