Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.48 |
| ▸ | TAS1R2 | Q8TE23 | 4/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2466133 | 1.00 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL2464636 | 1.00 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL599611 | 1.00 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL2464634 | 1.00 | TAS1R3 (0.48) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL23748757 | 0.84 | TAS1R3 (0.67) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL4712243 | 0.84 | TAS1R3 (0.67) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL29961639 | 0.84 | TAS1R3 (0.67) | TAS1R3TAS1R1TAS1R2MTNR1AMTNR1B | |
| SCHEMBL7740807 | 0.83 | MEN1 (0.54) | MTNR1AMTNR1BMEN1ALDH1A1KMT2A | |
| SCHEMBL2442157 | 0.83 | MEN1 (0.54) | MTNR1AMTNR1BMEN1ALDH1A1KMT2A | |
| SCHEMBL8838880 | 0.83 | MEN1 (0.54) | MTNR1AMTNR1BMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9403824-B2 | Pyridonemorphinan analogs and biological activity on opioid receptors | PURDUE PHARMA L.P. (US) | 2016-08-02 | — | — | US | disclosed |
| US-20150203494-A1 | PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS | PURDUE PHARMA L.P. | 2015-07-23 | — | — | US | disclosed |
| US-20150183787-A1 | PROPELLANE-BASED COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA L.P. | 2015-07-02 | — | — | US | disclosed |
| US-8980906-B2 | Pyridonemorphinan analogs and biological activity on opioid receptors | PURDUE PHARMA L.P. (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140187549-A1 | Pyridonemorphinan Analogs and Biological Activity on Opioid Receptors | PURDUE PHARMA L.P. (US) | 2014-07-03 | — | — | US | disclosed |
| EP-0738149-A4 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMA (IL) | 1999-10-27 | — | — | EP | disclosed |
| EP-0738149-A1 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1996-10-23 | — | — | EP | disclosed |
| WO-1995018617-A1 | 1-AMINOINDAN DERIVATIVES AND COMPOSITIONS THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 1995-07-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150183787-A1 | PROPELLANE-BASED COMPOUNDS AND THE USE THEREOF | OPRL1, OPRK1, OPRD1 | TAS1R3 721/4885TAS1R1 575/4885TAS1R2 885/4885 |
| US-20140187549-A1 | Pyridonemorphinan Analogs and Biological Activity on Opioid Receptors | OPRM1, OPRK1, OPRL1 | TAS1R3 905/4885TAS1R1 912/4885TAS1R2 1556/4885 |
| US-20150203494-A1 | PYRIDONEMORPHINAN ANALOGS AND BIOLOGICAL ACTIVITY ON OPIOID RECEPTORS | OPRM1, OPRK1, OPRL1 | TAS1R3 837/4885TAS1R1 928/4885TAS1R2 1526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.