Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | DHFR | P00374 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TYMS | P04818 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26790950 | 0.74 | BRAF (0.61) | HPGDBRAFNPSR1MEN1KMT2A | |
| SCHEMBL5025892 | 0.72 | LMNA (0.66) | MEN1KMT2ACYP3A4DHFRPOLB | |
| SCHEMBL11841190 | 0.71 | P2RX4 (0.58) | HPGDBRAFNPSR1MEN1KMT2A | |
| SCHEMBL10634597 | 0.71 | NPC1 (0.47) | BRAFNPSR1MEN1KMT2ADHFR | |
| SCHEMBL11699978 | 0.71 | CYP3A4 (0.55) | HPGDCYP3A4POLBALDH1A1TLR7 | |
| SCHEMBL13325137 | 0.70 | ALDH1A1 (0.52) | HPGDMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL18931751 | 0.70 | HPGD (0.51) | HPGDMEN1KMT2ACYP3A4POLB | |
| SCHEMBL9409123 | 0.70 | SCN5A (0.51) | HPGDKMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1227299 | 0.70 | MAP4K1 (0.48) | HPGDNPSR1MEN1KMT2ACYP3A4 | |
| SCHEMBL19468886 | 0.69 | BACE1 (0.51) | HPGDMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0538332-B1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORP (US) | 1997-07-23 | — | — | EP | disclosed |
| US-5393755-A | Hypotensive agents, enzyme inhibitors | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |
| EP-0538332-A1 | POLYCYCLIC GUANINE DERIVATIVES. | SCHERING CORP (US) | 1993-04-28 | — | — | EP | disclosed |
| WO-1991019717-A1 | POLYCYCLIC GUANINE DERIVATIVES | SCHERING CORPORATION (US) | 1991-12-26 | — | — | WO | disclosed |