Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PDE5A | O76074 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10628035 | 0.79 | HTT (0.52) | MEN1KMT2AKDM4EMAPT | |
| SCHEMBL7446291 | 0.71 | HPGD (0.50) | BRAFDHFRMEN1KMT2AKDM4E | |
| SCHEMBL26790950 | 0.68 | BRAF (0.61) | BRAFDHFRMEN1KMT2AKDM4E | |
| SCHEMBL5457663 | 0.68 | NPC1 (0.52) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL5449490 | 0.67 | NPC1 (0.70) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL5025892 | 0.67 | LMNA (0.66) | RAB9ALMNADHFRMEN1KMT2A | |
| SCHEMBL325288 | 0.67 | PROKR1 (0.54) | LMNANPSR1MAPT | |
| SCHEMBL11841190 | 0.66 | P2RX4 (0.58) | BRAFMEN1KMT2AKDM4ENPSR1 | |
| SCHEMBL10634619 | 0.65 | NPC1 (0.67) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL4009041 | 0.65 | ADORA3 (0.41) | LMNABRAFMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4767858-A | Anti-arthritic pyrazolo-triazine derivatives | BIOMEASURE, INCORPORATED (US) | 1988-08-30 | — | — | US | claimed |
| EP-0207651-A2 | Anti-inflammatory 7-phenyl pyrazolo-[1,5A]-1,3,5-triazine derivatives | BIOMEASURE, INC. (US) | 1987-01-07 | — | — | EP | claimed |
| US-4767858-A | Anti-arthritic pyrazolo-triazine derivatives | BIOMEASURE, INCORPORATED (US) | 1988-08-30 | — | — | US | disclosed |
| US-4734414-A | Anti-inflammatory and anti-arthritic pyrazolo-[1,5-a]-1,3,5-triazine derivatives, compositions, and method of use therefor | BIOMEASURE, INC. (US) | 1988-03-29 | — | — | US | disclosed |