Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | DHFR | P00374 | 6/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | PDE4A | P27815 | 1/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15552139 | 0.83 | TDP1 (0.70) | LMNAL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL6247201 | 0.81 | TSHR (0.73) | LMNAL3MBTL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL18029436 | 0.80 | TDP1 (0.63) | L3MBTL1CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL15541182 | 0.80 | CYP1A2 (0.67) | LMNAL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5030381 | 0.80 | LMNA (1.00) | LMNAL3MBTL1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL11841190 | 0.78 | P2RX4 (0.58) | L3MBTL1CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL212874 | 0.78 | POLB (0.48) | LMNAL3MBTL1ALDH1A1DHFRKMT2A | |
| SCHEMBL6098546 | 0.78 | PDE4A (0.75) | LMNAL3MBTL1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19487245 | 0.77 | LMNA (0.77) | LMNAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14010912 | 0.77 | ALDH1A1 (0.66) | LMNAL3MBTL1CYP1A2CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450333-B2 | Molecules for regulating cell death | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2013-05-28 | — | — | US | disclosed |
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-11-20 | — | — | US | disclosed |
| US-20050038051-A1 | Novel molecules for regulating cell death | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287473-A1 | NOVEL MOLECULES FOR REGULATING CELL DEATH | AIFM1, BAX, HSPE1 | LMNA 1467/4885L3MBTL1 421/4885CYP1A2 4871/4885 |
| US-20050038051-A1 | Novel molecules for regulating cell death | AIFM1, BAX, HSPE1 | LMNA 1467/4885L3MBTL1 421/4885CYP1A2 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.